A targeted solution for a challenging cancer
Ovarian cancer remains one of the leading causes of gynecological cancer deaths worldwide, with approximately 6,000 new cases annually in Italy. Among the most difficult forms to treat is platinum-resistant ovarian cancer, often developing after standard chemotherapy fails. Until now, treatment options have been limited, but a breakthrough therapy is reshaping the medical landscape.
mirvetuximab soravtansine: a revolutionary approach
The European Commission has approved mirvetuximab soravtansine, the first antibody-drug conjugate (ADC) targeting the folate receptor alpha (FRα). This therapy is specifically designed for patients with platinum-resistant high-grade serous ovarian cancer who have undergone one to three prior treatment regimens.
The Phase 3 MIRASOL study demonstrated that the drug reduces the risk of disease progression by 35% compared to traditional chemotherapy, while also improving overall survival. This approach represents a milestone in precision medicine, targeting cancer cells directly while minimizing side effects.
The role of FRα biomarker
The folate receptor alpha (FRα) biomarker is highly expressed in approximately one-third of ovarian cancers. Identifying it is critical to determine eligibility for mirvetuximab soravtansine. With the newly approved diagnostic test, physicians can accurately select patients most likely to benefit from this therapy.
New hope for patients
With this approval, AbbVie not only strengthens its commitment to oncology but also addresses an unmet clinical need. The therapy not only improves survival rates but also enhances the quality of life by reducing side effects associated with traditional treatments.
“After ten years, we finally have an effective and targeted therapy for patients with platinum-resistant ovarian cancer,” stated Prof. Domenica Lorusso, gynecological oncology specialist.
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